• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Protein Tyrosine Phosphorylation

        互联网

        541
        Phosphorylated tyrosyl residues in proteins are quantitatively much less abundant in normal cells than phosphoserines or phosphothreonines, yet tyrosine phosphorylation plays a crucial role in cellular regulation, including cell transformation by viral oncogenes and the action of growth factors (Hunter and Cooper, 1985). The role of tyrosine phosphorylation in signal transduction has been neglected for some time in mature neurons, which are postmitotic cells, although the situation has changed dramatically over the past few years. For example, it has been discovered that receptors for neurotrophic factors, the chief example being nerve growth factor (NGF), are transmembrane protein-tyrosine kinases (PTKs) (Ip and Yancopoulos, 1994). In addition, molecular cloning techniques have allowed the identification of many protein-tyrosine kinases and phosphatases that are exclusively or preferentially expressed in nerve cells, in vertebrates as well as in Drosophila . Several PTKs and proteintyrosine phosphatases (PTPases) are critical in the regulation of neural differentiation, neurite growth, and pathfinding (Temple and Qian, 1995; Tessier-Lavigne, 1995).
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序