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        下载《Protein Structure,Stability, and Folding》

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        622
        pdf文件,263页,1.50M
        Protein Structure,Stability, and Folding
        Edited by
        Kenneth P. Murphy
        University of Iowa College of Medicine, Iowa City, IA

        © 2001 Humana Press Inc.
        999 Riverview Drive, Suite 208
        Totowa, New Jersey 07512

        下载目录在 /基础医学区/蛋白质技术专业组/pub/

        Preface

        In 1995, Humana Press published a book edited by Dr. Bret A. Shirley
        entitled Protein Stability and Folding: Theory and Practice. This book detailed
        the use of many of the most important techniques for studying the stability and
        folding of proteins, but emphasized the Practice more than the Theory. The current
        volume, Protein Structure, Stability, and Folding, is a companion to the
        earlier work. In this volume more emphasis is placed on the Theory, although
        chapters on exciting new experimental approaches are included. Together, the
        two volumes cover a broad range of experimental and computational approaches
        to studying and understanding protein structure, stability, and folding.
        Since the publication of Shirley's work, there have been many exciting
        advances in both theory and experiment. Advances in the power of theoretical
        approaches now make it feasible to calculate many aspects of protein stability
        and dynamics from knowledge of the structure. The present book, Protein
        Structure, Stability, and Folding includes chapters on these calculations, as
        well as approaches for calculating conformational entropy and performing
        molecular dynamics simulations of protein unfolding. New experimental
        approaches are also being used to look at stability and folding. These include
        the use of co-solvents, new applications of hydrogen exchange techniques,
        temperature-jump methods for looking at fast folding events, and new strategies
        for mutagenesis experiments.
        I would like to thank all the authors who contributed to this book for their
        hard work and extraordinary patience. I would also like to thank my colleagues
        in the Department of Biochemistry and especially the members of my laboratory
        for their encouragement in this project. Finally I would like to thank my
        wife, Lee, and my children, Kevin, Katie, and Ellen, whose love and faith
        make it all worthwhile.
        Kenneth P. Murphy
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