• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Methods for Assessing Effects of Wnt/-Catenin Signaling in Senescence of Mesenchymal Stem Cells

        互联网

        446
        Mesenchymal stem cells (MSCs) represent a main population of stem cells and can differentiate into multiple cell lineages. Recently, MSC transplantation has been applied to repair the malfunctioned tissues. However, increasing evidences show that some MSCs expanded in vitro and in the aged individuals become senescent. Capacity of senescent MSCs in repairing the tissues may decrease significantly. Interestingly, preventing MSC senescence is a powerful potential strategy to delay aging of individuals and promote application of cell therapy for treating aging-related diseases. Therefore, it is necessary to explore mechanisms of MSC senescence in detail. Methods to assess MSC senescence in vitro include induction of senescence, detection of senescent changes and investigation of the molecules involved in senescence. Here we describe the methods to detect MSC senescence induced with old serum and investigate effects of Wnt/β-catenin signaling on MSC senescence.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序