• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Detecting Ligands Interacting with Lipoprotein Lipase

        互联网

        526
        The primary role for lipoprotein lipase (LPL) is hydrolysis of triglycerides in chylomicrons and very low density lipoproteins (VLDL). This enzyme has also been implicated in the process of atherogenesis (for reviews see refs. 1 and 2 ). Additional enzymatic activities of LPL include retinyl ester hydrolysis and fatty acid ethyl ester synthesis (3 ,4 ). Recent studies from several laboratories suggest that LPL may have roles unrelated to its enzymatic activity. For example, LPL increases lipoprotein binding to matrix and lipoprotein binding and uptake by cells, a function that does not appear to require catalytic activity. Since LPL has domains that interact with lipid, apoB, and cell surface molecules, it has been suggested that LPL forms a bridge between lipoproteins and cell surfaces (see refs. in 2 ). This bridging function has been postulated to play a role in the accumulation of lipoproteins by cells in vivo.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序