Targeting Ischemic Ventricular Arrhythmias
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The purpose of this chapter is to ask why there has been so little success in developing new antiarrhythmic drugs and what can we do to increase our chances of success. Failure has been a fairly common theme in attempts to produce new antiarrhythmic drugs, particularly for lethal ventricular arrhythmias. The chapter considers old and new ways of finding novel drugs for lethal ventricular arrhythmias as a result of myocardial ischemia and infarction and describes new compounds selective for ischemia-induced ventricular tachycardia and fibrillation.
