Systemic Nitric Oxide Production in Human Malaria: I. Analysis of NO Metabolites in Biological Fluids

Nitric oxide (NO) and the related species nitrosothiols, have multiple important physiological and pathological roles in health and disease that have been extensively reviewed elsewhere (1 -6 ). In brief, NO is involved in modulating or mediating host resistance to tumors and microbes, regulation of blood pressure and vascular tone, neurotransmission, learning, neurotoxicity, and control of cellular growth, and differentiation.