Analysis of Coenzyme Q10 Content in Human Plasma and Other Biological Samples

Since its discovery in 1957, coenzyme Q₁₀ (CoQ₁₀ ) has been extensively studied for its important role as a redox carrier in the mitochondrial electron transport chain and for its role as a potent antioxidant in animal tissues (1 ,2 ). In addition, several reports indicate that deficiencies in CoQ₁₀ are implicated in heart disease, periodontal infections, and AIDS (3 –5 ). These observations have generated ever-expanding needs for simple and sensitive analytical methods to assess CoQ₁₀ content in biological materials.