Amplification Refractory Mutation System and Molecular Diagnostics
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Allele-specific polymerase chain reaction (PCR) was first described in 1989, with variations arising over the next few years such as allele-specific oligonucleotide PCR, mutant-allele-specific amplification (MASA), PCR amplification of specific alleles (PASA), and the amplification refractory mutation system (ARMS) (1 –5 ). For convenience, the term ARMS will be used here when referring to them collectively.
