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        In Vitro Assays to Study Epithelial Cell Differentiation

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        The development of in vitro systems for the culture of human epithelial cells has aided the study of epithelial cell transformation by the epitheliotrophic papilloma-viruses (1 ). Although long-term proliferation of keratinocytes in vitro can now be achieved, the tissue-culture environment is not optimal for differentiation, hampering the study of virus:cell interactions in differentiating epithelial cells.
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