PPARs: History and Advances
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Peroxisome proliferator-activated receptors (PPARs) are members of the steroid hormone receptor superfamily, discovered in
1990. To date, three PPAR subtypes have been identified; PPARα, PPAR β/δ, and PPARγ. These receptors share a high degree of
homology but differ in tissue distribution and ligand specificity. PPARs have been implicated in the etiology as well as treatment
of several important diseases and pathological conditions such as diabetes, inflammation, senescence-related diseases, regulation
of fertility, and various types of cancer. Consequently, significant efforts to discover novel PPAR roles and delineate molecular
mechanisms involved in their activation and repression as well as develop safer and more effective PPAR modulators, as therapeutic
agents to treat a myriad of diseases and conditions, are underway. This volume of Methods in Molecular Biology
contains details of experimental protocols used in researching these receptors.
