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Localization of Calpain by Immunofluorescence in Adherent Cells

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580
Many of the early studies on the localization of calpain described a cytosolic distribution. However, it is becoming clear that calpain can play an essential role in regulating signal transduction across members of the integrin family of adhesion receptors and that in order to do this it is recruited to sites of ligand-occupied integrin.
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