The Ca2+-Activated Monovalent Cation-Selective Channels TRPM4 and TRPM5
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In this review we summarize the current data on the ion channels TRPM4 and TRPM5. These proteins are to date the only molecular candidates for the class of Ca2+ -activated cation channels (CAN channels). They form monovalent cation-selective and Ca-impermeable ion channels, which are activated by a rise of the cytosolic Ca2+ concentration. They have been described in a plethora of tissues, and their physiological importance is only now being explored since knockout mice have become available.
