CD1a/CD1b/CD1c/CD1d分子
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CD1a/CD1b/CD1c/CD1d分子
CD1a
常用单克隆抗体或代号：T6，Leu6
主要表达细胞：Thy，DCsub，LHC，Bsub T细胞
分子质量(kDa)和结构：gp49(IgSF)
功 能：与β2m组成MHCI类样分子，有抗原提呈功能
CD1b
常用单克隆抗体或代号：WM-25，4A7．6，NUT2
主要表达细胞：Thy，DC，LHC，Bsub T细胞
分子质量(kDa)和结构：gP45(IgSF)
功 能：与β2m组成MHCI类样分子，有抗原提呈功能
CD1c
常用单克隆抗体或代号：L161，M241，7(26
主要表达细胞：Thy，IX；sub，LHC，Bsub T细胞
分子质量(kDa)和结构：gp43(IgSF)
功 能：与β2m组成MHCI类样分子，有抗原提呈功能
CD1d
主要表达细胞：Thy，DC，LHC，Bsub，肠道上皮细胞 T细胞
分子质量(kDa)和结构：(IgSF)
功 能：与β2m组成MHCI类样分子，有抗原提呈功能
CD1
Family of non-polymorphic MHC class I-like glycoproteins
Also member of immunoglobulin superfamily
On chromosome 1q22-23 (not MHC linked)
Has 5 different subsets, all noncovalently associated with 12 kd beta 2 microglobulin
Function: restrict T cell responses to certain antigens; may mediate thymic T cell development
Positive staining (normal): cortical thymocytes (70%), activated T cells, Langerhans cells, interdigitating dendritic cells
Positive staining (disease): pre T ALL with cortical thymocyte phenotype; Langerhans cell histiocytosis
Negative staining: mature peripheral T cells
CD1a
Positive staining (normal): Dendritic cells in dermis/epidermis of benign inflammatory skin disorders
Positive staining (disease): Langerhans cell histiocytosis (fairly specific), myeloid leukemias, some B cell malignancies; dendritic cells in most peripheral cutaneous T cell lymphomas, AJCP 2001;116:72
Negative staining: normal B cells, most cutaneous peripheral B cell lymphomas (? reflects replacement of reactive pattern containing dendritic cells with a neoplastic pattern of B cells)
Micro images: Langerhans cell histiocytosis
Micro images (AJSP subscribers): pulmonary Langerhans cell histiocytosis
Micro images (Hum Path subscribers): Langerhans cell histiocytosis
References: AJSP 2001;25:630
CD1b
Positive staining (disease): myeloid leukemias and some B cell malignancies
Negative staining: normal B cells
CD1c
Positive staining (normal): subset of normal peripheral B cells
Positive staining (disease): myeloid leukemias and some B cell malignancies
Negative staining: normal B cells
CD1d
