CD1a/CD1b/CD1c/CD1d分子
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	CD1a/CD1b/CD1c/CD1d分子  
	CD1a
	常用单克隆抗体或代号:T6,Leu6
	主要表达细胞:Thy,DCsub,LHC,Bsub T细胞
	分子质量(kDa)和结构:gp49(IgSF)
	功    能:与β2m组成MHCI类样分子,有抗原提呈功能
	CD1b
	常用单克隆抗体或代号:WM-25,4A7.6,NUT2
	主要表达细胞:Thy,DC,LHC,Bsub T细胞
	分子质量(kDa)和结构:gP45(IgSF)
	功    能:与β2m组成MHCI类样分子,有抗原提呈功能
	CD1c
	常用单克隆抗体或代号:L161,M241,7(26
	主要表达细胞:Thy,IX;sub,LHC,Bsub T细胞
	分子质量(kDa)和结构:gp43(IgSF)
	功    能:与β2m组成MHCI类样分子,有抗原提呈功能
	CD1d
	主要表达细胞:Thy,DC,LHC,Bsub,肠道上皮细胞 T细胞
	分子质量(kDa)和结构:(IgSF)
	功    能:与β2m组成MHCI类样分子,有抗原提呈功能 
	
		 
	
		 
	
		 
	
		 
	
		 
	
		 
	
		CD1
	
		Family of non-polymorphic MHC class I-like glycoproteins
	
		Also member of immunoglobulin superfamily
	
		On chromosome 1q22-23 (not MHC linked)
	
		Has 5 different subsets, all noncovalently associated with 12 kd beta 2 microglobulin
	
		Function: restrict T cell responses to certain antigens; may mediate thymic T cell development
	
		Positive staining (normal): cortical thymocytes (70%), activated T cells, Langerhans cells, interdigitating dendritic cells
	
		Positive staining (disease): pre T ALL with cortical thymocyte phenotype; Langerhans cell histiocytosis
	
		Negative staining: mature peripheral T cells
	
		CD1a
	
		Positive staining (normal): Dendritic cells in dermis/epidermis of benign inflammatory skin disorders
	
		Positive staining (disease): Langerhans cell histiocytosis (fairly specific), myeloid leukemias, some B cell malignancies; dendritic cells in most peripheral cutaneous T cell lymphomas, AJCP 2001;116:72
	
		Negative staining: normal B cells, most cutaneous peripheral B cell lymphomas (? reflects replacement of reactive pattern containing dendritic cells with a neoplastic pattern of B cells)
	
		Micro images:  Langerhans cell histiocytosis
	
		Micro images (AJSP subscribers): pulmonary Langerhans cell histiocytosis
	
		Micro images (Hum Path subscribers): Langerhans cell histiocytosis
	
		References:  AJSP 2001;25:630
	
		CD1b
	
		Positive staining (disease): myeloid leukemias and some B cell malignancies
	
		Negative staining: normal B cells
	
		CD1c
	
		Positive staining (normal): subset of normal peripheral B cells
	
		Positive staining (disease): myeloid leukemias and some B cell malignancies 
	
		Negative staining: normal B cells
	
		CD1d
	










