Cranial Window Assessments in Experimental aSAH in Mice

The chronic cranial window model offers the possibility of a direct in vivo assessment of the cortical surface and pial vasculature in multiple physiological and pathological CNS states. Within the last years, attention has been paid to inflammatory and microvascular changes after acute subarachnoid haemorrhage (aSAH). In combination with different assessment and recording methods, the chronic cranial window is a powerful tool to study a variety of functional and structural values in vivo with a high temporal and spatial resolution. This chapter comprises details about the technical procedure and standard as well as alternative assessment modalities, which can be used in combination with the chronic cranial window model for in vivo analyses.