Nonisotopic In Situ Hybridization: Gene Mapping and Cytogenetics
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With the advent of nonradioactive probes during the past decade, in situ hybridization has become an immensely valuable tool in the hands of:
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Developmental biologists and cell biologists for the detection of mRNA in cells and tissue sections (1 –7 ),
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Virologists for detection of viral DNA and RNA (8 ), and
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Molecular cytogeneticists in detecting chromosome aberrations in interphase cells (Interphase Cytogenetics, especially Cancer Genetics, 9 –11 ), sex determination (12 ,13 ), and gene mapping by nonisotopic in situ hybridization (NISH, 14 ,15 ).
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