Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinsons Disease and Stroke

To maximize the success of any translational research endeavor, sensitive and reliable behavioral outcome measures in valid animal models are essential. A common goal of preclinical studies in both Parkinson’s disease and stroke is to reduce or reverse sensorimotor impairments associated with damage to the striatum and sensorimotor cortex. Here, we describe several behavioral tests of sensorimotor function that have been shown to be sensitive to varying degrees of nigrostriatal and cortical damage in both rats and mice and are highly useful for preclinical studies of potential therapeutics.