Construction of Photo-Cross-Linked Microarrays of Small Molecules

Small molecule microarrays are one of the most promising approaches to screen ligand molecules for individual proteins of interest. However, their potential has not been fully realized due to the limited number of methods to introduce small molecules onto the solid surfaces. To expand the compatibility of small molecule microarrays, we have developed a unique photo-cross-linking approach for immobilizing various small molecules, including natural products, on glass slides.