Co-immunoprecipitation of Tumor Suppressor Protein-Interacting Proteins

Tumor suppressor proteins, like most proteins, require interacting with other proteins in the cell to function properly. These interacting proteins may be regulators or substrates of this tumor suppressor protein. A tumor suppressor protein may also associate with its interacting proteins to form a functional complex to perform an activity. Identification and characterization of proteins that associate with a tumor suppressor protein can provide important information for the tumor suppressor’s function and how this function is regulated.