• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        CD71分子

        互联网

        4942
        CD71 分子
         
        CD71
        常用单克隆抗体或代号: OKT9;(TfR)
        主要表达细胞: Mac,增殖细胞 [NL]
        分子质量(kDa)和结构: p95(同源二聚体)
        功    能:合白细胞生长
         
        CD71
        Aka transferrin receptor
        Present on actively proliferating cells; essential for iron transport into proliferating cells (benign and malignant)
        Ferrotransferrin binds CD71 at neutral pH, is internalized to an acidic endosomal compartment
        Iron-free apotransferrin remains bound to CD71 at pH 5, is returned to cell surface, where pH rises to 7.4.
        At neutral pH, apotransferrin loses affinity for receptor, is released into circulation, allowing a new cycle to begin
        Positive staining (normal): all proliferating cells plus iron requiring cells: reticulocytes, erythroid precursors, capillary endothelium in brain
        Positive staining (disease): AML M6, primary effusion lymphoma

         
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序