• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        NPY Y5 Receptor Subtype: Pharmacological Characterization with Antisense Oligodeoxynucleotide Screening Strategy

        互联网

        612
        Neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are endogenous 36-amino acid peptides belonging to the same family. Different receptor subtypes have been identified in the NPY/PYY/PP family (1 ), and mammalian subtypes are now classified collectively as NPY receptors, several of which (namely Y1, Y2, Y4, Y5, and Y6) have been cloned (2 10 ). Based on studies using full-length peptides, C- or N-terminal fragments, and modified peptides of the NPY/PYY/PP family (11 ,12 ), the NPY Y5 receptor subtype was proposed as a mediator of NPY-induced feeding. At the time when the NPY Y5 receptor was cloned, neither NPY Y5 antagonists nor NPY Y5 knockout mice were available. Therefore we used an antisense oligodeoxynucleotide (antisense ODN) strategy to assess the proposed role of the NPY Y5 receptor subtype in the regulation of feeding.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序