• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Generation of Blood-Derived Human Dendritic Cells for Antitumor Immunotherapy

        互联网

        608
        Dendritic cells (DC) are a family of bone-marrow-derived professional antigen presenting cells (APC) with sparse, but wide, tissue distribution (1 ). They are classified primarily based on their localization: as interdigitating reticulum cells when present in lymphoid organs, as veiled cells when present in afferent lymph, as Langerhans cells when present in the epidermis, and as dermal dendritic cells when found in the dermis. Although DC are widely dispersed throughout the body, they exhibit many common features: an irregular shape with elongated dendritic processes, a distinctive cell-surface phenotype, low buoyant density, active motility, and the ability to stimulate vigorous proliferation of unprimed T cells. Like other professional APC such as macrophages and B cells, DC are able to ingest, process, and present antigen (Ag) in the context of major histocompatability (MHC) molecules. However, owing to their high expression of MHC class I and II, as well as costimulatory molecules and adhesion molecules, DC have the ability to induce primary T-cell-dependent immune responses in vivo and in vitro. This unique feature gives dendritic cells a central role in controlling immunity.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序