Generation of Human Type 1- and Type 2-Polarized Dendritic Cells from Peripheral Blood

Dendritic cells (DCs) are the most potent inducers of immune responses and potent regulators of immunity. They act as sentinel cells in the peripheral tissues, playing a key role in the development of effective immune responses to different types of pathogens (1 ). At the same time, DC dysfunction may play a pathogenic role in different diseases, ranging from autoimmunity to chronic infections and cancer, and multiple pathogens developed ways to interfere with DC functions as a mean to avoid eradication by the immune system and to enhance their own survival within infected hosts (2 ).