In Vivo Knockout of a Tissue-Specific Gene by Synthetic Ribozymes
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The enzymatic activity of RNA molecules has been a source of surprises ever since 1981 when Cech discovered this new aspect of RNA function (1 ,2 ). Its role as messenger and structural component in the translational process was suddenly transcended, and it is now evident that various RNA molecules can catalyze RNA splicing, ligation and, most importantly in the present context, cleavage of nucleic acids.
