Bone Marrow Transplantations to Study Gene Function in Hematopoietic Cells
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All cellular components of the blood originate from hematopoietic stem cells in the bone marrow. These pluripotent stem cells give rise to two lineages of specialized cells (Fig. 1 ). The lymphoid lineage produces B- and T-cells; the myeloid lineage gives rise to leukocytes, erythroblasts (the precursors of erythrocytes), and megakaryocytes (which produce platelets) (1 ).
Fig. 1. Hematopoietic stem cell-derived lineages.
