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Detection of HBV DNA by Oligonucleotide Probing

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Hepatitis B virus (HBV) DNA is present in the blood of patients with acute or chronic HBV infection at concentrations representing up to hundreds of millions of virions per milliliter of plasma. Detection of HBV DNA was feasible, if not particularly sensitive, even before development of methods based on the polymerase chain reaction (PCR).
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