CD68分子

CD68

Aka KP-1

May have role in macrophage phagocytic activities

Specific to lysosomes, not cell lineage

Positive staining (normal): macrophage/monocytes, basophils, dendritic cells, mast cells, myeloid cells, CD34+ progenitor cells, neutrophils, osteoclasts, activated platelets, B and T cells

Positive staining (tumors): AML-M4/M5, angiosarcoma (granular cell type), B cell lymphoma (some), giant cell angioblastoma, granular cell tumors, hairy cell leukemia, histiocytic sarcoma, interdigitating dendritic cell sarcoma (AJSP 2002;26:530), Langerhans cell histiocytosis, mastocytosis, mast cell disease (also positive for tryptase, CD43, CD117), melanoma (some)

Micro images: multinucleated giant cell in thyroid gland giant cell granuloma (figure C), plexiform fibrohistiocytic tumor, Rosai-Dorfman disease#1, #2-figure D

Micro images (AJSP subscribers): histiocytic lymphoma (figure A), histiocytic sarcoma (figure A), giant cell angioblastoma #1 (figure 5D), #2 (figure 6D)

Micro images (Mod Path subscribers): Kupffer cells in normal liver, Kupffer cells in severe non-alcoholic steatohepatitis (figure B)

Reference: AJSP 2001;25:1372, AJSP 2003;27:258, Mod Path 2002;15:699