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        Outer Membrane Protein Purification

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        689
        The major outer membrane proteins (OMPs) from Neisseria meningitidis , which are expressed at high levels, are subdivided in five classes based on molecular weight (1 ,2 ) (see Table 1 ).
        Table 1  Major Meningococcal Outer-Membrane Proteins

        Outer-membrane proteins

        Name

        Molecular maass

        Function/characteristics

        Class 1

        PorA

        44–47 kDa

        Por in

        Class 2/3

        PorB

        37–42 kDa

        Por in

        Class 4

        Rmp

         

        R eductionm odifiablep rotein, unknown

        Class 5

        Opa

        26–30 kDa

        Adhesion,opa city protein

        Opc

        25 kDa

        Invasion, opacity protein

        Iron-regulated proteins

        Mirp

        37 kDa

        Iron acquisition (?);m ajori ron-r egulatedp rotein

        FrpB

        70 kDa

        Ferric enterobactin receptor (also FetA)

        Adapted from ref. (1 ).
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