Modification of Human U1 snRNA for Inhibition of Gene Expression at the Level of Pre-mRNA
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U1 snRNA is a component of the U1 snRNP complex, which contains seven common snRNP proteins and three specific U1 snRNP proteins (1 ). It initiates spliceosome association with pre-mRNA by defining the 3′ boundary of exons (2 ). As the splicing reaction proceeds, U1 snRNP and the other spliceosome components are sequentially released from the transcript (3 ).
