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        【资源】New and Emerging Proteomic Techniques 电子书一本

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        与大家分享电子书一本New and Emerging Proteomic Techniques

        Preface

        Ever since its first definition, proteomics has been referred to as the study of
        the full set of proteins encoded by a genome, and qualitative and quantitative
        comparisons of proteomes under different conditions to further unravel bio-
        logical processes. Initially, proteomics was mainly a technology-driven field,
        centered on two-dimensional gels/mass spectrometry and LC-MS/MS
        approaches, which offered the ability to detect hundreds of proteins in a single
        analysis. Proteomics has since evolved into a wide-ranging discipline that
        includes a plethora of technologies and approaches whose subject is the study
        of proteins. However, as proteomics is entering into the realms of clinical and
        diagnostic applications, the enabling techniques are coming under an increased
        level of scrutiny. Significant weaknesses in some technological aspects have
        thus become apparent. As a result, new and improved proteomics techniques
        are being developed and propagated.
        It is the intent of New and Emerging Proteomic Techniques to present some
        of the newer and still developing proteomics tools and techniques that enable
        enhanced protein analyses. The techniques span the entire spectrum of top-
        down and bottom-up approaches, and in their sum offer a clear example of how
        proteomics has embraced essentially all techniques that contend with protein
        analysis. From microarrays and gels, to chromatography and affinity separa-
        tions, the proteomics techniques described in this book are addressing every
        aspect of the human proteome, both quantitative and qualitative. The methods
        of protein detection utilized are also very diverse, ranging from fluorescence
        and resonance light scattering, to surface plasmon resonance and mass spec-
        trometry. Furthermore, several chapters describe a combination of two or more
        distinct techniques, resulting in enabling approaches for proteome analysis.
        There are also three chapters that describe advanced bioinformatics approaches,
        as they are becoming increasingly important in the analysis of the complex
        proteomics data.
        New and Emerging Proteomic Techniques is aimed at both beginners and
        more experienced practitioners in the field of proteomics. Beginners will find
        it very useful to have such a diverse set of techniques assembled in a single
        book, serving as a valuable reference when choosing a technique that can
        address a specific proteomics question. For experienced proteomics research-
        ers, the book offers protocols and know-how from the pioneers and the expert
        users of each of these techniques, with details that are usually not found in a
        typical research publication. We are well aware that there are other proteomicsapproaches that are not represented in this book. However, we feel that the
        fifteen chapters included describe some of the most promising new and emerg-
        ing proteomics techniques, and hope that at least some of them will become
        proteomics mainstays in the years to come.
        Finally, we would like to thank all of our colleagues who kindly contributed
        their time and expertise for the assembly of New and Emerging Proteomic
        Techniques.

        Dobrin Nedelkov
        Randall W. Nels

        下载 http://www.rayfile.com/files/0a6370c0-acda-11dd-80ac-0014221b798a/

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