• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Ion Transport and Volume Measurements in Cell Cultures

        互联网

        633
        Studies on transmembrane ion movements in brain cells are of fundamental importance to understanding brain function. Thus, studies on the content and fluxes of major ions such as K+ , Na+ , Cl , and Ca2+ in neurons are critical to understanding the effects of conductance changes during excitatory or inhibitory events (Hille, 1984; Katz, 1966), and changes in Ca2+ conductance are critical for transmitter release (Hille, 1984; Douglas, 1978) Changes in pHalso affect membrane conductances (Moody, 1983). The complexities of the ion transport processes present in the major nonneuronal cells of the brain (glia, endothelia, and ependyma) are also now beginning to be appreciated and studied, and many of these processes appear to be electrically silent. Such processes appear likely to be involved in control of extracellular ion concentrations and pH and thus will also be important for neuronal function (Varon and Somjen, 1979; Kimelberg and Bourke, 1982; Kimelberg and Ransom, 1986). Exaggeration of such processes may underly the swelling of astroglia frequently seen in various pathological states (Kimelberg and Ransom, 1986). The maintenance of low intracellular sodium concentrations ([Na+ ],) is also important for maintaining inward Na+ gradients for secondary active cotransport of transmitters and other substances into both neurons and glia (Fonnum et al., 1980).
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序