Assessing Toxic Injuries of Experimental Therapeutics to the Crystalline Lens Using Lens Explant Culture
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Cataract formation during preclinical drug safety assessment studies can be a devastating safety finding during drug development
based on the stage at which these findings usually occur. The lens explant culture models offer an extremely versatile and
simple in vitro model to screen compound for such toxic liabilities or to study possible mechanisms of toxicity. The following
chapter is designed to highlight numerous examples of cataract formation during the drug development process, techniques used
to prepare the model and some approaches used to understand drug-induced cataract formation in vitro from a mechanistic, screening
and species sensitivity perspective.
