• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Cationic Liposome-Mediated DNA Delivery to the Lung Endothelium

        互联网

        470
        The lung endothelium has been studied as one of the most important sites for systemic DNA delivery using nonviral vectors. This is because not only does the lung play a critical role in maintaining the O2 /CO2 concentration in blood, but it also has the largest capillary bed and an extensive cell surface area to allow DNA to bind to and enter the endothelial cells. An additional advantage of the lung endothelium for DNA delivery is that the entire blood volume circulates through the lung and thus, the intravenously injected DNA molecules have full excess to the lung endothelium. Furthermore, blood flow through the pulmonary capillaries is slow and discontinuous. On inspiration, as the alveoli fill with air, blood flow slows and stops. On expiration, blood flow resumes. Slower blood flow in the lung favors DNA binding to the endothelial cells.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序