• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Methods of Purification of Heat Shock Protein-Peptide Complexes for Use as Vaccines Against Cancers and Infectious Diseases

        互联网

        585
        Immunization of mice, with preparations of heat shock proteins (HSPs) isolated from tumors or virus-infected cells, has been shown to elicit specific protective immunity against the tumor or the virus-infected cells used as the source of the HSP. This phenomenon has been shown to be general, in that specific immunogenicity of tumor-derived HSP preparations has been demonstrated in the cases of hepatoma (1 ), fibrosarcoma (2 -8 ), lung carcinoma (9 ), prostate cancer (10 ), spindle cell carcinoma (9 ), colon carcinoma (9 ), and melanoma (9 ), in mice and rats of different haplotypes. These tumors include chemically induced (1 -8 ), UV-induced (11 ) and spontaneous tumors (9 ), and efficacy has been demonstrated in prophylactic (1 -8 ,10 ,11 ) as well as in therapeutic models (9 ). In the case of viral models, HSP preparations from cognate cells have been shown to elicit a virus-specific cellular immune response against influenza virus (12 ), SV40 (13 ), vesicular stomatitis virus (14 ) and lymphocytic choriomeningitis virus (15 ). HSP preparations from cells transfected with model antigens (Ags) such as ovalbumin and β-galactosidase have been shown to elicit Ag-specific cytotoxic T-lymphocytes (CTL)s against ovalbumin (16 ) or β-galactosidase, respectively (17 )
        The immunogenicity of HSP-peptide complexes has obvious applications in vaccination against cancers and infectious diseases (18 ). With respect to cancers, HSP-peptide complexes isolated from a patient’s cancer can serve as customized, patient-specific therapeutic vaccines (19 ).
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序