• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        The Genetic Basis of Microbial Resistance to Antimicrobial Peptides

        互联网

        487
        Small cationic peptides with antibiotic properties have been isolated from a diverse array of evolutionarily divergent organisms, including insects, amphibians, mammals, and plants. They contribute to the innate immunity of the host by fending off opportunistic (i.e., environmental) microorganisms. Moreover, antimicrobial peptides present a chemical barrier early in infection before the mammalian host induces the specific type of immune response constituted by antibodies and T cells (1 ,2 ). Microorganisms have coexisted with their animal hosts for millions of years and have, in turn, evolved strategies that enable them to avoid or withstand the various microbicidal activities of the host (3 ). For example, the mammalian pathogen Salmonella typhimurium has several genes that confer resistance to host defense peptides, presumably allowing it to successfully colonize host tissues that are rich in antimicrobial peptides. The demonstration that mutants of S. typhimurium that are hypersusceptible to the killing effects of host-defense peptides are attenuated for virulence in mice has established that resistance to small cationic peptides is a virulence property of Salmonella (4 ) and, potentially, of other enteric pathogens.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序