• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Improved HSV-1 Amplicon Packaging System Using ICP27-Deleted, Oversized HSV-1 BAC DNA

        互联网

        1292
        Herpes simplex virus type 1 (HSV-1) has several unique features that make it a promising candidate for gene transfer vehicles. These include: i) a pantropic viral envelope; ii) a large genome (approx 152 kb), which confers its large transgene capacity; and iii) the ability of entering a latency state in neurons with limited transcriptional activity (see refs. 1 3 ). Moreover, HSV-1 is among the most extensively studied and characterized viruses, which has facilitated development of HSV-1-based vectors. Two distinct types of vectors, recombinant and amplicon, have been reported. Recombinant HSV-1 vectors use most of the viral genome as the vector backbone and can carry one or more gene(s) of interests inserted in place of the viral genes. On the other hand, amplicon vectors contain only the minimum cis-acting sequences from HSV-1 that are required for replication and packaging in the presence of HS V-1 helper functions in trans. In this chapter, we will describe the recent advance in packaging of helper virus-free HSV-1 amplicon vectors.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序