Visualization of DNA Topoisomerases by Electron Microscopy
互联网
468
Eukaryotic DNA Topoisomerase II (Topo II) is an essential enzyme that catalyzes the relaxation of supercoiled DNA and the segregation of newly replicated chromosomes (1 -3 ). The enzyme is highly conserved through evolution, and appears to result from the fusion of the A- and B-subunits of bacterial DNA gyrase (4 ). It has an A2 dimeric structure, whereas the bacterial enzyme has an A2 B2 tetrameric arrangement.
