• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Regulation of AP-1 Activity by TGF

        互联网

        896
        The activator protein-1 (AP-1) transcriptional complex is composed of DNA binding proteins belonging to the Jun and Fos proto-oncogene families, which play an important role in cell proliferation and transformation (reviewed in ref . 1 ). AP-1 activity is required to stimulate many genes that are induced following growth factor and cytokine treatment, and also is required for transformation mediated by oncogenes such as ras (2 ). Members of the Jun family can homodimerize or heterodimerize with each other or Fos family members, which cannot bind DNA on their own. The dimerization, which is mediated by a leucine zipper motif, allows the complex to bind to a consensus DNA sequence 5′-TGA G/C TCA-3′, termed an AP-1 site. This same sequence was found in several 12-O -tetradecanoylphorbol-13-acetate (TPA)-responsive genes and, hence, is also designated a TRE or TPA-responsive element. Heterodimers can form between c-Jun and ATF-2, a member of the CREB (CRE binding) protein family, allowing the complex to bind to CRE (cAMP regulatory element) sites, which differ from an AP-1 site by one nucleotide (3 ,4 ).
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序