• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Effects of Selective Immunotoxic Lesions on Learning and Memory

        互联网

        674
        Immunotoxins provide the opportunity to make neurotoxic lesions of specific neurochemically-defined neuronal populations (see Chapter 17) by targeting cell-surface antigens that are uniquely expressed by the cells of interest. The greatest application of these toxins in the study of learning and memory has been through the use of one specific immunotoxin, 192 IgG-saporin, which kills neurons that express the low-affinity nerve growth factor (NGF) receptor (1 , 2 ). The low-affinity NGF receptor (sometimes referred to as the p75 neurotrophin receptor) within the central nervous system is expressed by neurons in the basal forebrain and by cerebellar Purkinje cells (3 5 ). Within the basal forebrain, this receptor is expressed only on cholinergic neurons (6 ). Therefore, when this toxin is injected into the basal forebrain, it produces selective lesions of cholinergic neurons, sparing noncholinergic neurons at the lesion site (7 ). This lesion method has been employed to create an animal model of the degeneration of basal forebrain cholinergic neurons seen in patients with Alzheimer’s disease (8 ). Such a model has been impossible to achieve with other lesion methods that do not produce selective damage to basal forebrain cholinergic neurons, limiting the interpretation of behavioral deficits observed after such lesions.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序