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        CD54分子

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        2091
        CD54 分子
         
        CD54
        常用单克隆抗体或代号: WEHI- CAMI,OKT27;(ICAM- 1)
        主要表达细胞: 广泛 [AS]
        分子质量(kDa)和结构: gp90- 115(IgSF)
        功    能: 与LFA- 1、Mac- 1和CD43结合,细胞间粘附,鼻病毒受体,En上恶性疟原虫受体
         
        CD54
        Aka ICAM-1 (intercellular adhesion molecule 1); ligand for LFA-1 (CD50)
        Receptor for rhinovirus, malaria infected erythrocytes
        Involved in adhesion of neutrophils to endothelium at site of inflammation
        Reacts with CD11a / CD18 or CD11b / CD18 resulting in immune reaction or inflammation
        Positive staining (normal): broad, B and T cells, monocytes, endothelial cells, epithelial cells (various)
        Positive staining (tumors): keratoacanthoma (more in fully developed lesions with inflammatory infiltrate), cutaneous squamous cell carcinoma
        Micro images (Mod Path subscribers): keratoacanthoma, poorly differentiated squamous cell carcinoma
        Reference: Mod Path 2003;16:8

         
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