CD54分子
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CD54 分子
CD54
常用单克隆抗体或代号： WEHI- CAMI,OKT27;(ICAM- 1)
主要表达细胞： 广泛 [AS]
分子质量(kDa)和结构： gp90- 115(IgSF)
功 能： 与LFA- 1、Mac- 1和CD43结合,细胞间粘附,鼻病毒受体,En上恶性疟原虫受体
CD54
Aka ICAM-1 (intercellular adhesion molecule 1); ligand for LFA-1 (CD50)
Receptor for rhinovirus, malaria infected erythrocytes
Involved in adhesion of neutrophils to endothelium at site of inflammation
Reacts with CD11a / CD18 or CD11b / CD18 resulting in immune reaction or inflammation
Positive staining (normal): broad, B and T cells, monocytes, endothelial cells, epithelial cells (various)
Positive staining (tumors): keratoacanthoma (more in fully developed lesions with inflammatory infiltrate), cutaneous squamous cell carcinoma
Micro images (Mod Path subscribers): keratoacanthoma, poorly differentiated squamous cell carcinoma
Reference: Mod Path 2003;16:8
