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        《Handbook of Industrial Cell Culture》

        互联网

        1853

        Handbook of Industrial Cell Culture: Mammalian, Microbial, and Plant Cells

        Humana Press| 1588290328 | Edition - 2002-12-06 | PDF | 546 pages| 3.9 MB

        A diverse team of researchers, technologists, and engineers describe, in simple and practical language, the major current and evolving technologies for improving the biocatalytic capabilities of mammalian, microbial, and plant cells. The authors present state-of-the-art techniques, proven methods, and strategies for industrial screening, cultivation, and scale-up of these cells, and describe their biotech and industrial uses. Special emphasis is given to the solving critical issues encountered during the discovery of new drugs, process development, and the manufacture of new and existing compounds. Other topics include recombinant protein expression, bioinformatics, high throughput screening, analytical tools in biotechnology, DNA shuffling, and genomics discovery.

        Table of Contents

        Part I. Mammalian Cell Culture

        Analysis and Manipulation of Recombinant Glycoproteins Manufactured in Mammalian Cell Culture

        Nigel Jenkins

        Genetic Approaches to Recombinant Protein Production in Mammalian Cells

        Peter P. Mueller, Dagmar Wirth, Jacqueline Unsinger, and Hansjörg Hauser

        Protein Expression Using Transgenic Animals

        William H. Velander and Kevin E. van Cott

        Mammalian Cell Culture: Process Development Considerations

        Steven Rose, Thomas Black, and Divakar Ramakrishnan

        Part II. Microbial Cell Culture

        Natural Products: Discovery and Screening

        Matthew D. Hilton

        Genetic Engineering Solutions for Natural Products in Actinomycetes

        Richard H. Baltz

        Culture Medium Optimization and Scale-Up for Microbial Fermentations

        Neal C. Connors

        Part III. Plant Cell Culture

        Functional Genomics for Plant Trait Discovery

        Sam Reddy, Ignacio M. Larrinua, Max O. Ruegger, Vipula K. Shukla, and Yuejin Sun

        Molecular Tools for Engineering Plant Cells

        Donald J. Merlo

        Plant Cell Culture: A Critical Tool for Agricultural Biotechnology

        Joseph F. Petolino, Jean L. Roberts, and Ponsamuel Jayakumar

        Expression of Recombinant Proteins via the Plastid Genome

        Jeffrey M. Staub

        Oleosin Partitioning Technology for Production of Recombinant Proteins in Oil Seeds

        Maurice M. Moloney

        Part IV. Critical Tools for Biotechnology

        Genome Sequencing and Genomic Techniques in Drug Discovery and Development

        Lawrence M. Gelbert

        Proteomics

        Gerald W. Becker, Michael D. Knierman, Pavel Shiyanov, and John E. Hale

        Metabolic Flux Analysis, Modeling, and Engineering Solutions

        Walter M. van Gulik, Wouter A. van Winden, and Joseph J. Heijnen

        Advances in Analytical Chemistry for Biotechnology: Mass Spectrometry of Peptides, Proteins, and Glycoproteins

        Jeffrey S. Patrick

        DNA Shuffling for Whole Cell Engineering

        Steve del Cardayre and Keith Powell

        Cell Culture Preservation and Storage for Industrial Bioprocesses

        James R. Moldenhauer

        Index

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