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        Oligonucleotides as Inhibitors of Protein Synthesis

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        819
        Duplex formation between an oligonucleotide and a strand of mRNA can effectively inhibit the expression of a specific gene via interfering with the cellular protein synthesis process. The antisense technology (1 ) is regarded as a powerful tool in molecular biology. Advances in the field have also led to the development of many pharmaceutical/therapeutic applications, with a number of oligonucleotides undergoing human clinical trials at present (2 ). Making the best use of this approach requires a good understanding of the subject, careful planning, a knowledge of limitations and pitfalls, and a capacity to go beyond the basic antisense techniques.
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