Appendix: Compendium of DNA Topoisomerase Sequences

DNA topoisomerases can be grouped in to three families based on biochemical properties and amino acid sequence. Following are multiple protein sequence alignments of the members of each of these families: the eukaryotic DNA topoisomerase I type, the DNA topoisomerase II type, and the DNA topoisomerase III/eubacterial DNA topoisomerase I type. These sequences were obtained from data in the public data bases and represent the most reliable data available as of GenBank release 95.0, June 15, 1996 (1 ). These alignments are updates of alignments published previously (2 ).