前沿科技及其它

Lung cancer is one of the most common cancers afflicting the citizens of developed countries (1). While the lung is a complex tissue composed of over 40 different cell types, the most common lung cancers, large cell lung carcinoma, small cell lung carcinoma (SCLC), squamous cell carcinoma, and adeno ...

Cancer is a multistep progressive disease of increasing genomic instability. Genomic instability is a condition where the cell looses the ability to retain the semi-conservative means of its genome replication because of vital controlling mechanisms dysfunction. Thus, replica ...

The value of early detection is clear from current tests for specific cancers: self-examination and mammography for breast, prostate-specific antigen (PSA) for prostate, and Pap smears for cervical cancers. No such method exists for early detection of lung cancer. New methods are being des ...

Lung cancer is a highly aggressive neoplasm, a characteristic that is reflected by the multitude of genetic aberrations detectable on the chromosomal and molecular level. In order to understand these seemingly chaotic chromosomal alterations, we have performed Comparative Geno ...

Gene amplifications and deletions frequently contribute to tumorigenesis. The characterization of DNA copy-number changes by Comparative Genomic Hybridization (CGH) has shown that these changes are not occurring randomly. As summarized in the previous chapter, recurring p ...

As discussed in previous chapters, lung cancer is one of most deadly diseases and conventional treatments for lung cancer patients are largely ineffective. Presented with at least four major histological types oflung cancers, dependable tools for early detection and diagnosis of each ...

Lung cancer is the leading cause of cancer death among men and women in the United States with 170,000 deaths per year. This exceeds the sum of the next three leading causes of death due to cancer: breast, colon, and prostate. There are over 1 million deaths worldwide due to lung cancer, making it truly an epidemic. ...

Lung cancer is the second cause of death after cardiovascular diseases and is the major cause of cancer deaths in the Western world. Lung cancer can be divided into two main categories, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Due to the enormity of the problem of lung cancer thr ...

cAMP-dependent protein kinase (PKA) is involved in various cellular functions such as cell proliferation, gene induction, and metabolism (1,2) and its regulatory subunits have been suggested as a drug target for cancer and other diseases (3). PKA is composed of two catalytic (C) and two regula ...

Lung cancer is the number one cause of cancer-related death in the US. In 2001, it is estimated that approx 180,000 new patients will be diagnosed, and close to 90% of them will die of the disease (1). The major reasons for such dismal prognoses are the lack of effective preventive and early therapeutic interve ...

The successful treatment of lung cancer, as with all cancers, is determined by the selectivity of the therapy. That is, the cells that have undergone carcinogenic changes must be eradicated, while normal cells must be preserved. With therapeutic agents that are not discriminating, signifi ...

“Hypothesis-driven chemoprevention of lung cancer, when put to the test of randomized large-scale clinical trials, so far has been disappointing, unlike important successes with selective estrogen receptors modulators for breast cancer and non steroidal anti-inflammatory d ...

Lung cancer is the leading cause of cancer death in the United States (1). Many tumors, including lung cancer, have the capacity to promote immune tolerance and escape host immune surveillance (2). Tumors utilize numerous pathways to inhibit immune responses including the elaboration of imm ...

The central importance of functional host professional antigen-presenting cell (APC) in the immune response against cancer has been well-defined (1). Dendritic cells (DC) are highly specialized professional APC with potent capacity to capture, process, and present antigen to T cells ...

Murine models of pulmonary tumors have long provided investigators a reliable and reproducible method of testing the therapeutic efficacy of adoptive immunotherapy. Adoptive immunotherapy involves the generation of tumor-specific immune cells which, following activat ...

The rapid advances that have taken place in tumor immunology within the past decade have fostered renewed interest in the use of immune-based therapies for the treatment of cancer (1,2). Numerous strategies, which aim to provoke and augment anti-tumor immunity in cancer patients, have been de ...

Limited advances have occurred in lung cancer prevention and treatment (1), which has necessitated the investigation of other means of intervention.As cancer is a disease of altered cellular homeostasis and genetic damage, programmed cell death (PCD) has gained increasing importa ...

Antisense oligonucleotides (AONs) are one of the several types of “antisense therapeutics” designed to modulate specific gene expression at the mRNA level. Although antisense strategies also include ribozymes (RNA enzyme) and, more recently, DNAzymes (a DNA analog of a ribozyme), AONs ...

Inactivation of p53wt, a tumor-suppressor gene, has been observed in a majority of small cell and non-small cell lung cancers (SCLC/NSCLC) (1,2). Many tumors that frequently metastasize to lung, such as colon, breast, liver, melanoma, and bone, also exhibit a high incidence of p53 mutations and del ...

Lung cancer is one of the leading causes of cancer death in the world (1). The high mortality rate for lung cancer may be due to either or both the absence of standard clinical procedures for early diagnosis of tumors compared to breast, prostate, and colon cancers, and lack of effective treatments in more ad ...