生物信息学技术

Abstract Table of Contents Figures Literature Cited Abstract Hardklör and Krönik are software tools for feature detection and data reduction of high?resolution mass spectra. Hardklör is used to reduce peptide isotope distributions to a sin

Abstract Table of Contents Figures Literature Cited Abstract The identification of peptides and proteins by LC?MS/MS requires the use of bioinformatics. Tools developed in the Tabb Laboratory contribute significant flexibility and discrimi

Abstract Table of Contents Figures Literature Cited Abstract The Bluejay genome browser is a stand?alone visualization tool for the multi?scale viewing of annotated genomes and other genomic elements. Bluejay allows users to customize disp

Abstract Table of Contents Figures Literature Cited Abstract The BLAST?Like Alignment Tool (BLAT) is used to find genomic sequences that match a protein or DNA sequence submitted by the user. BLAT is typically used for searching similar se

Abstract Table of Contents Figures Literature Cited Abstract Online Mendelian Inheritance in Man (OMIM) is a comprehensive compendium of information on human genes and genetic disorders, with a particular emphasis on the interplay between

Abstract Table of Contents Materials Figures Literature Cited Abstract Phosphorylation is the most studied protein post?translational modification (PTM) in biological systems, since it controls cell growt

Abstract Table of Contents Materials Figures Literature Cited Abstract Large?scale, quantitative analysis of gene expression can be accomplished by microarray or RNA?seq analysis. While these methods are

Abstract Table of Contents Materials Figures Literature Cited Abstract This unit describes basic protocols on using the non?B DNA Motif Search Tool (nBMST) to search for sequence motifs predicted to form

Abstract Table of Contents Materials Figures Literature Cited Abstract Cloud computing has revolutionized availability and access to computing and storage resources, making it possible to provision a larg

Abstract Table of Contents Figures Literature Cited Abstract Innovations in biomedical research technologies continue to provide experimental biologists with novel and increasingly large genomic and high?throughput data resources to be ana

Abstract Table of Contents Figures Literature Cited Abstract KEGG (Kyoto Encyclopedia of Genes and Genomes) is a bioinformatics resource for understanding the functions and utilities of cells and organisms from both high?level and genomic

Abstract Table of Contents Materials Figures Literature Cited Abstract FlowRepository.org is a Web?based flow cytometry data repository provided by the International Society for Advancement of Cytometry (

Abstract Table of Contents Materials Figures Literature Cited Abstract Biological indicators have numerous and widespread utility in personalized medicine, but the measurement of these indicators also pos

Abstract Table of Contents Materials Figures Literature Cited Abstract Inductively Coupled Plasma Mass Spectrometry (ICP?MS) is a highly sensitive elemental analysis technique that has been widely applied

Abstract Table of Contents Figures Literature Cited Abstract Over the last 20 years, there has been an explosion in the amount and type of biological and chemical data that has been made publicly available in a variety of online databases.

Abstract Table of Contents Figures Literature Cited Abstract The selection, acquisition, and use of high?quality small molecule libraries for screening is an essential aspect of drug discovery and chemical biology programs. Screening libra

Abstract Table of Contents Figures Literature Cited Abstract Crossbow is a scalable, portable, and automatic cloud computing tool for identifying SNPs from high?coverage, short?read resequencing data. It is built on Apache Hadoop, an imple

Abstract Table of Contents Materials Figures Literature Cited Abstract Affinity purification coupled with mass spectrometry (AP?MS) is a robust technique used to identify protein?protein interactions. Wit

Abstract Table of Contents Materials Figures Literature Cited Abstract Significance Analysis of INTeractome (SAINT) is a software package for scoring protein?protein interactions based on label?free quant

Abstract Table of Contents Figures Literature Cited Abstract The Human Gene Mutation Database (HGMD) constitutes a comprehensive core collection of data on germ?line mutations in nuclear genes underlying or associated with human inherited