MSA-2 dimer,2377881-92-8

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MSA-2 dimer

CAS No. : 2377881-92-8

MCE 国际站：MSA-2 dimer

产品活性：MSA-2 dimer 是一种具有选择性和口服活性的非核苷酸 STING 激动剂 (K_d=145 μM)，有长期抗肿瘤和免疫原活性。MSA-2 dimer 作为非共价二聚体与 STING 结合，其渗透率高于循环二核苷酸。

研究领域：Immunology/Inflammation

作用靶点：STING

In Vivo: MSA-2 dimer (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival.
?MSA-2 dimer (40 mg/kg; s.c.; 25 days) induces complete tumor regression.
?MSA-2 dimer (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) level in tumors.
?MSA-2 dimer (60 mg/kg; s.c.; 4 hours) concentrations is observed in tumors than in plasma or other nontumor tissues .
?MSA-2 dimer (THP-1 cells) induces phosphorylation of both TBK1 and IR. MSA-2 dimer (10 μM and 33 μM; macrophages) induces IFN-β.
?MSA-2 dimer also exhibits dose-dependent antitumor activity.

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