Uric acid尿酸钠,1198-77-2

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Uric acid sodium

CAS No. : 1198-77-2

MCE 国际站：Uric acid sodium

产品活性：Uric acid sodium (Monosodium urate) 是氧自由基 (oxygen radical) 的清除剂，是一种非常重要的抗氧化剂，有助于维持血压的稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species  |  Endogenous Metabolite

In Vitro: Uric acid (400 μM; 48 hours) sodium protects Caco-2 cells from indomethacin-induced lipid peroxidation.
Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) sodium significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) sodium is higher than that in cells treated with indomethacin alone. Uric acid sodium has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity.

In Vivo: Uric acid (250 mg/kg; p.o.) sodium ameliorates indomethacin-induced enteropathy.
Oral administration of uric acid sodium decreases ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy.

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