KP1019,124875-20-3

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KP1019

CAS No. : 124875-20-3

MCE 国际站：KP1019

产品活性：KP1019 (FFC14A) 是一种基于 Ru(III) 的抗转移和细胞毒性抗癌剂。 KP1019 在癌细胞中诱导 DNA 损伤和细胞凋亡 (apoptosis)。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: KP1019 is internalized by yeast and induces mutations, cell cycle delay, and cell death. KP1019 sensitivity of strains defective in DNA repair is examined, ultimately showing that rad1Δ, rev3Δ, and rad52Δ yeast are hypersensitive to KP1019, suggesting that nucleotide excision repair (NER), translesion synthesis (TLS), and recombination each play a role in drug tolerance.
KP1019 inhibits proliferation of ovarian tumor cells, induces DNA damage and apoptosis in colon carcinoma cells. KP1019 causes interstrand cross-links and bulky DNA adducts in mammalian cell lines.

In Vivo: KP1019 treatment inhibits primary tumour growth in in the model of MCa mammary carcinoma. None of the treatments reduced the development of lung metastatases in this tumour model.

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