NC1 CLAC-P (14–27)

免疫组织化学 (IHC) 常用的肿瘤标志物抗体

是肝细胞生长因子 (HGF) 的受体。正常的 HGF/MET 信号通路精密调控胚胎发育、组织再生和损伤修复过程中的细胞增殖、分化和迁移。 在肺癌中，MET 可通过基因扩增、蛋白过表达或 14 号外显子 (METex14) 跳跃突变等方式异常激活，导致下游促生长和生存信号通路持续活化，驱动肺癌的生长、存活和转移。MET 扩增/过表达是 EGFR 靶向治疗获得性耐药的重要机制之一[6]。   图 3.人肺癌组织的 MET 免疫组化分析 (HY-P86238)。         Section

Cultures of Proliferating Vascular Smooth Muscle Cells from Adult Human Aorta

Abnormal proliferation of human vascular smooth muscle cells (hVSMCs) is a central event in the development of atherosclerosis (1 –3 ) As a result, there is considerable interest in the establishment of hVSMC cultures as a mode

Enzyme-Prodrug Systems: Thymidine Phosphorylase/5-Deoxy-5-Fluorouridine

(5 ,6 ) that phosphorolytically cleaves thymidine to yield thymine and deoxyribose-1-phosphate (dR-1-P) (7 ,8 ). TP is expressed in various human cells and tissues and plays a role in plasma thymidine homeostasis (9 –11 ). The levels of expression in different human tissues