- ￥1900
- Biorigin
- BN40782R
- 2026年07月14日
- WB,
- Mouse,
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- 文献和实验
- 技术资料
- 适应物种：
Mouse,
- 应用范围：
WB,
- 抗体英文名：
NMUR1/GPR66
- 规格：
100ul
| 英文名称 | NMUR1/GPR66 |
| 中文名称 | G蛋白偶联受体66/神经调节肽U受体1抗体 |
| 别 名 | FM-3; G protein-coupled receptor 66; G-protein coupled receptor 66; G-protein coupled receptor FM-3; GPR66; Growth hormone secretagogue receptor family Member 3; Neuromedin U Receptor 1; Neuromedin-U receptor 1; NMU-R1; NMUR1; NMUR1_HUMAN. |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse NMUR1/GPR66:1-80/415 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Neuromedin U is a neuropeptide with high activity on smooth muscle. It is widely expressed in gastrointestinal systems and central nervous system (CNS). Peripheral activities of neuromedin U include smooth muscle stimulation, ion transport alterations in the gut and the regulation of local blood flow and adrenocortical function. Neuromedin U receptors 1 and 2 (NMUR1 and NMUR2) are multi-pass membrane proteins that belong to the G-protein coupled receptor 1 family of proteins. Both NMUR1 and NMUR2 act as receptors for the neuromedin U neuropeptide. NMUR1 is detected in peripheral organs, particularly in urogenital and gastrointestinal systems, with highest levels in testis. It’s expression in CNS is low, but the protein has been detected in cerebellum, hippocampus, dorsal root ganglia and spinal cord. NMUR2 is predominantly detected in central nervous system with highest levels detected in medulla oblongata, spinal cord and thalamus. It may also be detected in testis but has low levels of expression in peripheral tissues. Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q9HB89 Gene ID: 10316 Database links: Entrez Gene: 10316 Human Omim: 604153 Human SwissProt: Q9HB89 Human Unigene: 471619 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验减重6.9 kg、无神经副作用！CB1靶向药在肥胖与肿瘤领域迎来爆发
CNR1编码大--麻素受体1（CB1），是内源性大--麻素系统经典受体，在中枢神经系统高表达，也分布于肝脏、脂肪等外周代谢器官，参与食欲调控和能量代谢。近年来CNR1研究已从代谢性疾病拓展至肿瘤和纤维化领域。2025年monlunabant在II期试验中使肥胖患者减重6.4-6.9 kg；外周限制性CB1抗体nimacimab与司美格鲁肽联用减重13.2%且无神经精神副作用；新型CB1降解剂在3D肿瘤模型中抑制增殖并诱导凋亡；2026年研究发现CB1拮抗可减轻肾纤维化；大--麻素通过CB
特点 从细胞因子受体结构上看，细胞因子受体大体可以归为以下几个家族包括： 免疫球蛋白超家族，神经生长因子受体超家族（结构富含Cys）,趋化因子受体（G蛋白偶联受体）典型细胞因子受体超家族（红细胞生成素受体家族和干扰素受体家族）。 多数细胞因子受体是一种受体性酪氨酸蛋白激酶，也可看成是一种跨膜的别构调节酶。酶活性受非催化结构域调节。细胞外的结构域与细胞因子相结合行使正调控，而细胞内除了催化部位以外的结构域可能行使负调控；跨膜部位则把细胞外刺激与细胞内的信号发生器相偶联，完成跨膜信号转导 第十
质、DNA和RNA合成中起作用。锰在自然界分布广泛，以茶叶中含量最丰富。镁的缺乏较少。若吸收过多可出现中毒症状，主要由于生产及生活中防护不善，以粉尘形式进入人体所致。锰是一种原浆毒，可引起慢性神经系统中毒，表现为锥体外系的功能障碍。并可引起眼球集合能力减弱，眼球震颤、睑裂扩大等。 五、硒 硒是人体必需的一种微量元素，体内含量约14-21mg，广泛分布于除脂肪组织以外的所有组织中。主要以含硒蛋白质形式存在。人体每日硒的需要量为50－200μg。 硒是谷胱甘肽过氧化物酶(GSH�x
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