- ￥351 - 5663
- MedChemExpress(MCE)
- 美国
- HY-13862
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
612487-72-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥351.0 |
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
| 规格： | 100 mg | 产品价格： | ￥5663.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
AZD1080
CAS No. : 612487-72-6
MCE 国际站：AZD1080
产品活性：AZD1080 是一种有效的选择性 GSK3 抑制剂。AZD1080 抑制重组人 GSK3α 和 GSK3β，pKi (IC50) 分别为 8.2 (6.9 nM) 和 7.5 (31 nM)。
研究领域：PI3K/Akt/mTOR | Stem Cell/Wnt
作用靶点：GSK-3
In Vitro: AZD1080 shows selectivity against cdk2 (pKi=5.9; 1150 nM; 37-fold), cdk5 (pKi=6.4; 429 nM; 14-fold), cdk1 (pKi=5.7; 1980 nM; 64-fold) and Erk2 (pKi< 5; >10 μM; >323-fold). AZD1080 (at 10 μM) is also evaluated for pan-kinase selectivity and showed good overall selectivity versus 23 kinases, as well as against 65 different receptors, enzymes and ion channels in MDS Pharma screen (< 50% effect at 10 μM AZD1080). Concentration-dependent inhibition of tau phosphorylation is observed for AZD1080 (IC50=324 nM) and the non-selective reference GSK3 inhibitor LiCl (IC50=1.5 mM) indicating that AZD1080 is several orders of magnitude more potent than LiCl.
In Vivo: The pharmacokinetic analysis in blood after oral administration revealed that AZD1080 has a good oral bioavailability in rats (15-24%) with a half-life of 7.1 h, making AZD1080 attractive for further in vivo testing. The subchronic (3 days) oral treatment with AZD1080 at 4 or 15 μmol/kg significantly blocked the MK-801-induced memory deficit (AZD1080 vs. MK-801, p<0.05 at 4 μmol/kg and p<0.01 at 15 μmol/kg) in mice, raising the hypothesis that longer treatment may be required to prime the synapses to function effectively.
相关产品：Bioactive Compound Library Plus | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Aging Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Neurodegenerative Disease-related Compound Library | Anti-Obesity Compound Library | Glucose Metabolism Compound Library | Targeted Diversity Library | Antidepressant Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Serine/Threonine Kinase Inhibitor Library | Laduviglusib | SB 216763 | Bisindolylmaleimide I | Kenpaullone | LY2090314 | GSK 3 Inhibitor IX | Ceftriaxone sodium salt | TWS119 | Tideglusib | AR-A014418 | 1-Azakenpaullone | Cromolyn sodium | IM-12 | AZD2858 | CHIR-98014 | hSMG-1 inhibitor 11j | TDZD-8 | 9-ING-41 | R547 | CP21R7 | Indirubin-3'-monoxime | SB 415286 | Lithium chloride hydrate | KY19382 | BRD0705 | RGB-286638 | BRD3731 | Bikinin
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验. 次日抽血后置37℃温箱，温育15 min后检测，同时推血涂片显微镜下观察血小板，血常规结果示：WBC 5.38×109/L, Hb 120 g/L, 血小板184×109/L，显微镜下血小板散在分布，数量正常. 后查患者冷凝集效价高于正常. 1.2病例2.患儿，男，7 mo龄，因血尿、贫血原因待查入院. 住院后查血常规：WBC 17.14×109/L,RBC 1.72×1012/L,Hb 64 g/L, 血小板47×109/L,因患儿RBC，Hb及血小板严重偏低，临床医师嘱其到门诊
Inducible shRNA Lentiviral Vectors
of your expression clone. 3) Cotransfect the ViraPower™ Packaging Mix and pLenti6/V5-GW/miR expression plasmid DNA into 293FT Cells using Lipofectamine™ 2000. 4) Harvest virus-containing supernatants 48-72 hours post-transfection. 4. Titering
Preparation of Poly A+ RNA and Northern Analysis
Protocols; leave out Percoll step) first, then extract mRNA. To extract from cultured cells (ie. HT1080), begin with one T75 flask (approx. 2 x 106 cells). 2) Have Pharmacia kit reagents warmed to RT for 30 min. Check if Extraction buffer is in solution
技术资料暂无技术资料 索取技术资料
